Pirinixic Acid Aminothiazole

Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Cay-14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively). It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms. Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Cay-20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.Formal Name: 2-[[4-chloro-6-[[4-(2-naphthalenyl)-2-thiazolyl]amino]-2-pyrimidinyl]thio]-octanoic acid. CAS Number: 1492060-44-2. Molecular Formula: C25H25ClN4O2S2. Formula Weight: 513.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 20 mg/ml. lambdamax: 208, 256, 308 nm. SMILES: ClC1=NC(SC(CCCCCC)C(O)=O)=NC(NC2=NC(C3=CC=C(C=CC=C4)C4=C3)=CS2)=C1. InChi Code: InChI=1S/C25H25ClN4O2S2/c1-2-3-4-5-10-20(23(31)32)34-25-28-21(26)14-22(30-25)29-24-27-19(15-33-24)18-12-11-16-8-6-7-9-17(16)13-18/h6-9,11-15,20H,2-5,10H2,1H3,(H,31,32)(H,27,28,29,30). InChi Key: BADFIDKPYNKNRT-UHFFFAOYSA-N.