PFI-90

PFI-90 is an inhibitor of lysine demethylases (KDMs). It inhibits KDM3B, KDM4B, KDM5A, and KDM6B by 46.8 to 87.1% when used at a concentration of 10 µM. PFI-90 induces cell death in SJSA-1 osteosarcoma and TC-32 Ewing's sarcoma cancer cells (IC50s = 2 and 1 µM, respectively).Formal Name: 2-(2-pyridinyl)hydrazide, 2-pyridinecarboxylic acid. CAS Number: 53995-62-3. Molecular Formula: C11H10N4O. Formula Weight: 214.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(C1=CC=CC=N1)NNC2=CC=CC=N2. InChi Code: InChI=1S/C11H10N4O/c16-11(9-5-1-3-7-12-9)15-14-10-6-2-4-8-13-10/h1-8H,(H,13,14)(H,15,16). InChi Key: GCZPXNWBXDWHKM-UHFFFAOYSA-N.