ML-335

ML-335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 µM, respectively, in Xenopus oocytes). It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML-335 activates K2P2.1/TREK1 by binding to the C-type gate, which is the active site of TREK channels.Formal Name: N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-benzamide. CAS Number: 825658-06-8. Molecular Formula: C15H14Cl2N2O3S. Formula Weight: 373.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml, Ethanol: 5 mg/ml. lambdamax: 258 nm. SMILES: CS(NC1=CC=C(C(NCC2=C(Cl)C=C(Cl)C=C2)=O)C=C1)(=O)=O. InChi Code: InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20). InChi Key: RDFIQTZRJRVFHK-UHFFFAOYSA-N.