ML-239

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in the MAPK, NF-kappaB, and inflammatory cytokine pathways. It is stable in saline and modestly stable in human plasma.Formal Name: 2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide. CAS Number: 1378872-36-6. Synonyms: CID-49843203. Molecular Formula: C13H10Cl3N3O2. Formula Weight: 346.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. lambdamax: 314 nm. SMILES: O=C(COC1=C(Cl)C=C(Cl)C=C1Cl)N/N=C/C2=CC=CN2. InChi Code: InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+. InChi Key: NVEDPFICKAIHKD-NGYBGAFCSA-N.