Misonidazole

Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.Formal Name: alpha-(methoxymethyl)-2-nitro-1H-imidazole-1-ethanol. CAS Number: 13551-87-6. Synonyms: NSC 261037, Ro 7-0582, SR 1354. Molecular Formula: C7H11N3O4. Formula Weight: 201.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 222, 317 nm. SMILES: OC(COC)CN1C=CN=C1[N+]([O-])=O. InChi Code: InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3. InChi Key: OBBCSXFCDPPXOL-UHFFFAOYSA-N.