MG149

MG149 is a histone acetyltransferase (HAT) inhibitor with IC50 values of 74 and 47 µM, for human recombinant Tip60 and males absent on the first (MOF) HATs, respectively. MG149 targets the acetyl-CoA binding site and inhibits acetyltransferase activity in the nuclear extract from murine hippocampus, amygdala, and prefrontal cortex. MG149 also inhibits the p53 and NF-kappaB pathways.Formal Name: 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid. CAS Number: 1243583-85-8. Molecular Formula: C22H28O3. Formula Weight: 340.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: OC1=C(C(O)=O)C(CCC2=CC=C(CCCCCCC)C=C2)=CC=C1. InChi Code: InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25). InChi Key: WBHQYBZRTAEHRR-UHFFFAOYSA-N.