LM-10

LM-10 is an inhibitor of tryptophan 2,3-dioxygenase (TDO, IC50 = 2 µM). It is selective for TDO over indoleamine 2,3-dioxygenase (IDO), monoamine oxidase A (MAO-A), and MAO-B, as well as a panel of various receptors and transporters, at 10 µM. LM-10 (1 mg/ml in the drinking water) reverses tumoral immune resistance in a TDO-overexpressing P815B mastocytoma syngeneic model using mice immunized with the P815 antigen P1A. Oral administration of LM-10 (50 mg/kg) prevents decreases in the number of dopaminergic neurons and increases in microglial cell volume, a marker of neuroinflammation, in the substantia nigra and inhibits decreases in intestinal transit in a mouse model of Parkinson's disease induced by rotenone (Cay-13995).Formal Name: 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole. CAS Number: 1316695-35-8. Molecular Formula: C11H8FN5. Formula Weight: 229.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml. lambdamax: 226, 328 nm. SMILES: FC1=CC=C2C(/C=C/C3=NN=NN3)=CNC2=C1. InChi Code: InChI=1S/C11H8FN5/c12-8-2-3-9-7(6-13-10(9)5-8)1-4-11-14-16-17-15-11/h1-6,13H,(H,14,15,16,17)/b4-1+. InChi Key: JDBSZVDIUIRSDG-DAFODLJHSA-N.