L-Methionine-(S,R)-Sulfoximine

L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine. It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 µM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.Formal Name: 2S-amino-4-(S-methylsulfonimidoyl)-butanoic acid. CAS Number: 15985-39-4. Molecular Formula: C5H12N2O3S. Formula Weight: 180.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: N[C@H](C(O)=O)CCS(C)(=N)=O. InChi Code: InChI=1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1. InChi Key: SXTAYKAGBXMACB-DPVSGNNYSA-N.