Kynurenic Acid (hydrate)

Kynurenic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via a kynurenine (Cay-11305) intermediate by kynurenine aminotransferases (KATs). Kynurenic acid is an antagonist of the NMDA and AMPA receptors as well as alpha7 nicotinic acetylcholine receptors (nAChRs, EC50s = 235, 101, and 7 µM, respectively). It is also an agonist of the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35, EC50s = 1.4 and 39 µM, respectively). It prevents lesioned hemisphere weight loss in a neonatal rat model of cerebral hypoxic-ischemia induced by carotid artery ligation when administered at a dose of 300 mg/kg. Kynurenic acid (1 and 5 mg/ml) is protective against rhabdomere neurodegeneration in the eye in an Htt93Q transgenic Drosophila model of Huntington's disease. Levels of kynurenic acid in cerebrospinal fluid are increased in patients with schizophrenia.Formal Name: 4-hydroxy-2-quinolinecarboxylic acid, hydrate. CAS Number: 345909-35-5. Synonyms: KYNA. Molecular Formula: C10H7NO3 . XH2O. Formula Weight: 189.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M NaOH: 1 mg/ml. lambdamax: 217, 247, 341 nm. SMILES: OC(C1=NC2=CC=CC=C2C(O)=C1)=O. InChi Code: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14). InChi Key: HCZHHEIFKROPDY-UHFFFAOYSA-N.