Harzianopyridone

Harzianopyridone is an atpenin-like inhibitor of mammalian and nematode mitochondrial complex II (succinate:ubiquinone oxidoreductase, SQR) with IC50 values of 0.017, 0.2, and 2 µM for bovine, rat, and nematode complex II, respectively. It also inhibits nematode quinol-fumarate reductase (QFR, IC50 = 0.36 µM). Harzianopyridone is selective for complex II over complexes I and III in rats and cattle and complex I in nematodes (IC50s >100 µM). It has antibacterial and antifungal activity (EC50s = 35.9, 42.2, 60.4, and 50.2 µg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively).Formal Name: 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-2(1H)-pyridinone. CAS Number: 137813-88-8. Synonyms: (-)-Harzianopyridone. Molecular Formula: C14H19NO5. Formula Weight: 281.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1NC(OC)=C(OC)C(O)=C1C([C@@H](C)C/C=C/C)=O. InChi Code: InChI=1S/C14H19NO5/c1-5-6-7-8(2)10(16)9-11(17)12(19-3)14(20-4)15-13(9)18/h5-6,8H,7H2,1-4H3,(H2,15,17,18)/b6-5+/t8-/m0/s1. InChi Key: FPYAYFJAGDIMEX-GJIOHYHPSA-N. Origin: Fungus/Trichoderma harzianum sp. FKI-1509.