H-9 (hydrochloride)

The H series isoquinolinesulfonamide protein kinase inhibitors are widely used to block signaling pathways in order to elucidate mechanisms of cellular regulation and signal transduction. H-9, an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively. H-9 has been used to reduce the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons and to inhibit PKA-mediated phosphorylation in a rat seizure model.Formal Name: N-(2-aminoethyl)-5-isoquinolinesulfonamide, dihydrochloride. CAS Number: 116700-36-8. Synonyms: Protein Kinase Inhibitor H-9. Molecular Formula: C11H13N3O2S . 2HCl. Formula Weight: 324.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217 nm. SMILES: NCCNS(=O)(=O)c1cccc2cnccc12. InChi Code: InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2. InChi Key: DCVZSHVZGVWQKV-UHFFFAOYSA-N.