Furafylline

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1. It was originally introduced as a bronchodilator with extended duration compared to theophylline, but then subsequently reported to inhibit the oxidation of caffeine (Cay-14118), a reaction catalyzed by CYP1A2.Formal Name: 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-1H-purine-2,6-dione. CAS Number: 80288-49-9. Molecular Formula: C12H12N4O3. Formula Weight: 260.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 272 nm. SMILES: O=C1C2=C(N=C(C)N2)N(CC3=CC=CO3)C(N1C)=O. InChi Code: InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14). InChi Key: KGQZGCIVHYLPBH-UHFFFAOYSA-N.