Fluphenazine (hydrochloride)

Fluphenazine is a dopamine D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM, respectively) and an active metabolite of fluphenazine decanoate (Cay-39903). It also binds to histamine H1, serotonin 5-HT2A, and 5-HT2B receptors (Kis = 45, 17, and 82 nM, respectively). It acts as an inverse agonist at H1 and 5-HT2A receptors. Fluphenazine is a typical antipsychotic compound. It induces extrapyramidal symptoms in animal models, including monkeys. Formulations containing fluphenazine have been used in the management of psychotic disorders.Formal Name: 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol, dihydrochloride. CAS Number: 146-56-5. Synonyms: SQ 4,918. Molecular Formula: C22H26F3N3OS . 2HCl. Formula Weight: 510.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. lambdamax: 259, 311 nm. SMILES: OCCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(C(F)(F)F)C=C4)CC1.Cl.Cl. InChi Code: InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29,,/h1-2,4-7,16,29H,3,8-15H2,2*1H. InChi Key: MBHNWCYEGXQEIT-UHFFFAOYSA-N.