DL-alpha-Difluoromethylornithine (hydrochloride hydrate)

DL-alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis. DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways. Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.Formal Name: 2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate. CAS Number: 96020-91-6. Synonyms: DFMO, Eflornithine. Molecular Formula: C6H12F2N2O2 . HCl [H2O]. Formula Weight: 236.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: FC(F)C(C(O)=O)(N)CCCN.Cl.O. InChi Code: InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9,,/h4H,1-3,9-10H2,(H,11,12),1H,1H2. InChi Key: FJPAMFNRCFEGSD-UHFFFAOYSA-N.