DCLK1-IN-1

DCLK1-IN-1 is an inhibitor of doublecortin-like kinase 1 (DCLK1, IC50 = 17 nM). It is selective for DCLK1 over leucine-rich repeat kinase 2 (LRRK2), bromodomain-containing protein 4 (BRD4), and ERK5 (IC50s = 7,000, >10,000, and 3,350 nM, respectively). DCLK1-IN-1 (1 µM) reduces the number of cells in primary patient-derived pancreatic cancer organoids. In vivo, DCLK1-IN-1 (10 mg/kg every other day) reduces plaque area and collagen levels in the aortic arches and serum levels of Tnf-alpha and Il-6 an ApoE-/- mouse model of atherosclerosis induced by a high-fat diet.Formal Name: 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5-(2,2,2-trifluoroethyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one. CAS Number: 2222635-15-4. Synonyms: DCLK1 Inhibitor 1, Doublecortin-like Kinase 1-IN-1, Doublecortin-like Kinase 1 Inhibitor 1. Molecular Formula: C26H28F3N7O2. Formula Weight: 527.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: CN(C1=CC=CC=C1C2=O)C3=NC(NC(C=CC(N(CC4)CCN4C)=C5)=C5OC)=NC=C3N2CC(F)(F)F. InChi Code: InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27,28)29/h4-9,14-15H,10-13,16H2,1-3H3,(H,30,31,32). InChi Key: OQFCHSFVWSLDAO-UHFFFAOYSA-N.