D13

D13 is an acylhydrazone antifungal. It is active against C. neoformans in vitro (MIC80 = 0.06 µg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection.Formal Name: 4-bromo-benzoic acid, 2-[(3,5-dibromo-2-hydroxyphenyl)methylene]hydrazide. CAS Number: 321945-27-1. Molecular Formula: C14H9Br3N2O2. Formula Weight: 476.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml. lambdamax: 244, 295, 307, 341 nm. SMILES: O=C(N/N=C/C1=CC(Br)=CC(Br)=C1O)C2=CC=C(Br)C=C2. InChi Code: InChI=1S/C14H9Br3N2O2/c15-10-3-1-8(2-4-10)14(21)19-18-7-9-5-11(16)6-12(17)13(9)20/h1-7,20H,(H,19,21)/b18-7+. InChi Key: QERLWOMVFDBAFP-CNHKJKLMSA-N.