D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)

D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM. Related inositol oligophosphates Ins(1,3,4,5)-P4, Ins(1,3,4,6)-P4, Ins(1,4,5,6)-P4, and Ins(1,3,4,5,6)-P5 do not inhibit the calcium channel at concentrations up to 100 µM. Ins(1,3,4)P3-mediated inhibition of Ins(3,4,5,6)-P4 1-kinase increases the cellular level of Ins(3,4,5,6)-P4, thus regulating channel inhibition. Ins(3,4,5,6)-P4 was found to be inactive when analyzed for Ca2+-releasing potency in Xenopus oocytes.Formal Name: D-myo-inositol-3,4,5,6-tetra(hydrogen phosphate), tetrasodium salt. Synonyms: Ins(3,4,5,6)-P4, 3,4,5,6-IP4. Molecular Formula: C6H12O18P4 . 4Na. Formula Weight: 588.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. SMILES: O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C6H16O18P4.4Na/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11,,,,/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20),,,,/q,4*+1/p-4/t1-,2+,3?,4?,5?,6?,,,,. InChi Key: DZJJWPAQUIBBLR-GUBBRYCUSA-J.