D-DOPA

D-DOPA is an enantiomer of the dopamine precursor L-DOPA (Cay-13248). It can be converted to L-DOPA via sequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, in rat kidney homogenates. It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner. Intraventricular administration of D-DOPA (200 µg/animal) increases striatal dopamine levels in rats. D-DOPA (20 mg/kg, i.p.) induces contralateral turns in a rat model of Parkinson's disease induced by 6-OHDA (Cay-25330).Formal Name: 3-hydroxy-D-tyrosine. CAS Number: 5796-17-8. Molecular Formula: C9H11NO4. Formula Weight: 197.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M HCl: 10 mg/ml. SMILES: OC1=CC(C[C@@H](N)C(O)=O)=CC=C1O. InChi Code: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14). InChi Key: WTDRDQBEARUVNC-UHFFFAOYSA-N.