Continentalic Acid

Continentalic acid is a diterpenic acid that has been found in A. continentalis and has diverse biological activities. It is active against methicillin-susceptible S. aureus (MSSA) and clinical isolates of methicillin-resistant S. aureus (MRSA, MICs = 8 and 8-16 µg/ml, respectively). Continentalic acid (200 µM) induces apoptosis in U-2932, OCI-LY1, and Ramos (RA 1) B cell lymphoma cells. It also improves renal function and decreases renal malondialdehyde (MDA) and peroxidase levels, nitric oxide (NO) production, and neutrophil infiltration in a mouse model of E. coli- and LPS-induced renal injury.Formal Name: (1R,4aS,4bR,7R,10aS)-7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic acid. CAS Number: 19889-23-7. Synonyms: Pimaradienoic Acid. Molecular Formula: C20H30O2. Formula Weight: 302.5. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: C[C@]12[C@@](CCC3=C[C@](C=C)(C)CC[C@]32[H])([H])[C@@](C)(CCC1)C(O)=O. InChi Code: InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18+,19+,20-/m1/s1. InChi Key: MHVJRKBZMUDEEV-XIHRTOKZSA-N. Origin: Plant/Aralia continentalis.