Clemizole (hydrochloride)

Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5, IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Cay-18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.Formal Name: 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, monohydrochloride. CAS Number: 1163-36-6. Synonyms: AL 20, Allercur. Molecular Formula: C19H20ClN3 . HCl. Formula Weight: 362.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 2 mg/ml. lambdamax: 205, 252, 276, 283 nm. SMILES: ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.Cl. InChi Code: InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22,/h1-2,5-10H,3-4,11-14H2,1H. InChi Key: DNFMJYXRIMLMBZ-UHFFFAOYSA-N.