Cdk4 Inhibitor

Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 µM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A. This compound has been shown to inhibit HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest.Formal Name: 2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. CAS Number: 546102-60-7. Synonyms: Cyclin-dependent kinase 4 Inhibitor. Molecular Formula: C20H10BrN3O2. Formula Weight: 404.2. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 236, 259, 271, 283, 318, 397 nm. SMILES: O=C1NC(C2=C1C(C(C=CC(Br)=C3)=C3N4)=C4C5=C2C6=C(C=CC=C6)N5)=O. InChi Code: InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26). InChi Key: NMFKDDRQSNVETB-UHFFFAOYSA-N.