BI-1467335

BI-1467335 is an inhibitor of vascular adhesion protein-1 (VAP-1, IC50 = 50s = >1,000 and >10,000 nM, respectively). Oral administration of BI-1467335 (10 mg/kg per day) reduces plasma total cholesterol, LDL, and glucose levels, as well as decreases the recruitment of macrophages to atherosclerotic lesions and the area of atherosclerotic plaques, in a cholesterol-fed rabbit model. It reduces neutrophil lung infiltration induced by K. pneumoniae in mice when administered at a dose of 6 mg/kg. It also reduces airway hyperreactivity in a mouse model of rhinovirus-exacerbated allergy-induced asthma.Formal Name: 4-[[(2E)-2-(aminomethyl)-3-fluoro-2-propen-1-yl]oxy]-N-(1,1-dimethylethyl)-benzamide, monohydrochloride. CAS Number: 1478364-68-9. Synonyms: PXS-4728A. Molecular Formula: C15H21FN2O2 . HCl. Formula Weight: 316.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.Cl. InChi Code: InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17,/h4-8H,9-10,17H2,1-3H3,(H,18,19),1H/b11-8+,. InChi Key: AEMZEDNMNLIDSL-YGCVIUNWSA-N.