Auranofin

Auranofin
Auranofin
   
COVID-19 Forschung
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay15316-25 25 mg -

6 - 10 Werktage*

74,00 €
Cay15316-100 100 mg -

6 - 10 Werktage*

133,00 €
Cay15316-500 500 mg -

6 - 10 Werktage*

516,00 €
Cay15316-1 1 g -

6 - 10 Werktage*

884,00 €
 
Auranofin is a gold-thiol complex with diverse biological activities. It inhibits thioredoxin... mehr
Produktinformationen "Auranofin"
Auranofin is a gold-thiol complex with diverse biological activities. It inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial peroxiredoxin 3 (PRDX3), and induces apoptosis in Jurkat T cells. Auranofin reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes. It is active against P. falciparum and S. mansoni in vitro when used at concentrations ranging from 1 to 10 µM. In vivo, auranofin (2 mg/kg per day) reduces the number of peripheral blood mononuclear cells (PBMCs) containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of simian immunodeficiency virus (SIV). Auranofin (0.5 µM) synergizes with buthionine sulfoxime (BSO) to decrease glutathione peroxidase 4 (GPX4) levels, increase intracellular accumulation of reactive oxygen species (ROS), and induce ferroptosis in Huh7 and HepG2 hepatocellular carcinoma cells.Formal Name: [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold. CAS Number: 34031-32-8. Synonyms: NSC 321521, Ridauragold thiol, SKF 39162. Molecular Formula: C20H34AuO9PS. Formula Weight: 678.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Ethanol: 4 mg/ml. SMILES: CC(O[C@@H]([C@@H]([C@@H](COC(C)=O)O1)OC(C)=O)[C@H]([C@@H]1[S-][Au+][P](CC)(CC)CC)OC(C)=O)=O. InChi Code: InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18,1-4-7(5-2)6-3,/h10-14,24H,5H2,1-4H3,4-6H2,1-3H3,/q,,+1/p-1/t10-,11-,12+,13-,14+,,/m1../s1. InChi Key: AUJRCFUBUPVWSZ-XTZHGVARSA-M.
Schlagworte: NSC 321521, Ridauragold thiol, SKF 39162, [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold
Hersteller: Cayman Chemical
Hersteller-Nr: 15316

Eigenschaften

Anwendung: Thioredoxin reductase inhibitor
MW: 678.5 D
Formel: C20H34AuO9PS
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 34031-32-8| Passende Produkte
KEGG ID : K00384 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H301, H361
P-Sätze: P201, P202, P264, P270, P280, P321, P330, P301+P310, P308+P313, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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COVID-19 Forschung
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