ATPA (hydrate)

ATPA is an agonist of ionotropic glutamate receptor 5 (GluR5/GluK1, Ki = 0.0043 µM). It is selective for GluR5 over GluR1-4 (Kis = 6-14 µM), as well as GluR6 (Ki = >1,000 µM). ATPA induces inward currents in HEK293 cells expressing recombinant human GluR5 and isolated rat dorsal root ganglion (DRG) neurons (EC50s = 2.1 and 0.6 µM, respectively).Formal Name: alpha-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-4-isoxazolepropanoic acid, hydrate. Molecular Formula: C10H16N2O4 . XH2O. Formula Weight: 228.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 10 mM. SMILES: NC(C(O)=O)CC1=C(C(C)(C)C)ONC1=O.O. InChi Code: InChI=1S/C10H16N2O4.H2O/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15,/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15),1H2. InChi Key: LKJZQCPVIAFMPE-UHFFFAOYSA-N.