APC 366 (trifluoroacetate salt)

APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 µM for human recombinant enzyme). It reduces maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs when used at a concentration of 1 µM. Aerosolized APC 366 (5 mg in 1 ml of water) reduces airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. It also reduces collagen content and expression of protease-activated receptor 2 (PAR-2) and alpha-smooth muscle actin (alpha-SMA) in rat liver in a model of bile duct ligation-induced liver fibrosis.Formal Name: N2-[(1-hydroxy-2-naphthalenyl)carbonyl]-L-arginyl-L-prolinamide, trifluoroacetate salt. Molecular Formula: C22H28N6O4 . XCF3COOH. Formula Weight: 440.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol:Water: 5 mg/ml (in 20% EtOH). SMILES: OC1=C(C(N[C@@H](CCCNC(N)=N)C(N2[C@H](C(N)=O)CCC2)=O)=O)C=CC3=CC=CC=C31.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C22H28N6O4.C2HF3O2/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29,3-2(4,5)1(6)7/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26),(H,6,7)/t16-,17-,/m0./s1. InChi Key: FFLIQFBAKJNSSS-QJHJCNPRSA-N.