ABT-594 (hydrochloride)

ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C- adrenergic receptors (Kis = 890, 597, and 342 nM, respectively), and 70 other receptors, enzymes, and transporters (Kis = >1,000 nM) in radioligand binding assays. ABT-594 induces [86Rb+] efflux in K177 cells transfected with human neuronal alpha4beta2 subunit-containing nAChRs (EC50 = 140 nM). In vivo, ABT-594 (0.05 and 0.01 mg/kg, s.c.) increases latency to paw withdrawal in a hot-plate test in rats. It also induces hypothermia, seizures, and an increase in blood pressure.Formal Name: 5-[(2R)-2-azetidinylmethoxy]-2-chloro-pyridine, monohydrochloride. CAS Number: 203564-54-9. Synonyms: Ebanicline, Tebanicline. Molecular Formula: C9H11ClN2O . HCl. Formula Weight: 235.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=CC=C(OC[C@@H]2NCC2)C=N1.Cl. InChi Code: InChI=1S/C9H11ClN2O.ClH/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7,/h1-2,5,7,11H,3-4,6H2,1H/t7-,/m1./s1. InChi Key: GYVARJONEFSAJB-OGFXRTJISA-N.