A-804598

A-804598 is a potent and selective competitive antagonist of the purinergic P2X7 receptor, a ligand-gated ion channel, with IC50 values of 9.9 and 10.9 nM in 132N1 cells transfected with the rat or mouse receptor, respectively. It inhibits IL-1beta release in human THP-1 cells stimulated with LPS and IFN-gamma (IC50 = 8.5 nM). A-804598 is selective for P2X7 receptors over other P2X and P2Y receptors at concentrations up to 100 µM and over many G protein-coupled receptors, enzymes, transporters, and ion channels. A-804598 (25 mg/kg) prevents footshock-induced increases in IL-1beta mRNA in the paraventricular nucleus of the rat hypothalamus.Formal Name: N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine. CAS Number: 1125758-85-1. Molecular Formula: C19H17N5. Formula Weight: 315.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml. lambdamax: 226, 304, 317 nm. SMILES: C[C@H](N/C(NC#N)=N\C1=CC=CC2=C1C=CC=N2)C3=CC=CC=C3. InChi Code: InChI=1S/C19H17N5/c1-14(15-7-3-2-4-8-15)23-19(22-13-20)24-18-11-5-10-17-16(18)9-6-12-21-17/h2-12,14H,1H3,(H2,22,23,24)/t14-/m0/s1. InChi Key: PQYCRDPLPKGSME-AWEZNQCLSA-N.