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LY294002
Artikelnummer: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
| Schlagworte: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Anwendung: | PI3K inhibitor |
| CAS | 154447-36-6 |
| MW: | 307.3 D |
ab 35,00 €
15-deoxy-Delta12,14-Prostaglandin J2
Artikelnummer: Cay18570-1
15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
| Schlagworte: | 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 87893-55-8 |
| MW: | 316.4 D |
ab 43,00 €
SU 5416
Artikelnummer: Cay13342-50
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2, FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 µM), SU 5416 also inhibits PDGFR (IC50 = 20 µM),...
| Schlagworte: | NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor,... |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 204005-46-9 |
| MW: | 238.3 D |
ab 164,00 €
Genipin
Artikelnummer: Cay10010622-25
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion. High levels of UCP2 expression can disrupt pancreatic beta cell function and downregulate insulin secretion thereby contributing to the...
| Schlagworte: | (+)-Genipin, 1R,4aS,5,7aS-tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester |
| Anwendung: | UCP2 inhibitor |
| CAS | 6902-77-8 |
| MW: | 226.2 D |
ab 24,00 €
SAHA
Artikelnummer: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
| Schlagworte: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
| Anwendung: | HDAC inhibitor |
| CAS | 149647-78-9 |
| MW: | 264.3 D |
ab 34,00 €
Doxorubicin (hydrochloride)
Artikelnummer: Cay15007-5
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
| Schlagworte: | DOX,... |
| Anwendung: | DNA topoisomerase II inhibitor, Antitumor agent |
| CAS | 25316-40-9 |
| MW: | 580 D |
ab 43,00 €
Cytochalasin D
Artikelnummer: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
| Schlagworte: | NSC 209835,... |
| Anwendung: | Cell-permeable actin polymerization inhibitor |
| CAS | 22144-77-0 |
| MW: | 507.6 D |
ab 83,00 €
LY379268
Artikelnummer: Cay15351-10
LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...
| Schlagworte: | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Anwendung: | mGluR2 / mGluR3 agonist |
| CAS | 191471-52-0 |
| MW: | 187.2 D |
ab 68,00 €
Peroxynitrite
Artikelnummer: Cay81565-1
Peroxynitrite is formed in vivo by the reaction of NO with superoxide. It is a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrate the aromatic residues of proteins.Formal Name: peroxynitrous acid, sodium salt. CAS Number: 14042-01-4. Synonyms: Sodium Peroxynitrite....
| Schlagworte: | Sodium Peroxynitrite, peroxynitrous acid, sodium salt |
| Anwendung: | Oxidizing agent |
| CAS | 14042-01-4 |
| MW: | 85 D |
62,00 €
n-Dodecyl-beta-D-maltoside
Artikelnummer: Cay16494-5
n-Dodecyl-beta-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins. In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation. The critical micelle...
| Schlagworte: | DDM, Dodecyl Maltoside, dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside |
| Anwendung: | Non-ionic detergent |
| CAS | 69227-93-6 |
| MW: | 510.6 D |
ab 84,00 €
DAPT
Artikelnummer: Cay13197-25
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
| Schlagworte: | GSI-IX, N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 208255-80-5 |
| MW: | 432.5 D |
ab 77,00 €
nor-NOHA (acetate)
Artikelnummer: Cay10006861-10
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nomega-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and...
| Schlagworte: | Nomega-hydroxy-nor-Arginine, 2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate |
| Anwendung: | Arginase inhibitor |
| CAS | 1140844-63-8 |
| MW: | 296.3 D |
ab 30,00 €