6-Aminonicotinamide

6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 µM). Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM). 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion. In addition, 6-AN causes glial neurodegeneration.Formal Name: 6-amino-3-pyridinecarboxamide. CAS Number: 329-89-5. Synonyms: 6-AN, NSC 21206, SR 4388. Molecular Formula: C6H7N3O. Formula Weight: 137.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 1 mg/ml. lambdamax: 269 nm. SMILES: Nc1ccc(cn1)C(=O)N. InChi Code: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10). InChi Key: ZLWYEPMDOUQDBW-UHFFFAOYSA-N.