5-Methoxycarbonylamino-N-acetyltryptamine

5-Methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) is a melatonin (Cay-14427) derivative and a partial agonist of melatonin receptor 1 (MT1) and MT2. It inhibits forskolin-induced production of cAMP in CHO cells expressing human MT1 or MT2 (EC50s = 440 and 98 nM, respectively). In vivo, ocular administration of 5-MCA-NAT reduces intraocular pressure in control and DBA/2J glaucomatous mice.Formal Name: N-[3-[2-(acetylamino)ethyl]-1H-indol-5-yl]-carbamic acid, methyl ester. CAS Number: 190277-13-5. Synonyms: GR135531, 5-MCA-NAT, MCA-NAT. Molecular Formula: C14H17N3O3. Formula Weight: 275.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly soluble. SMILES: O=C(C)NCCC1=CNC2=C1C=C(NC(OC)=O)C=C2. InChi Code: InChI=1S/C14H17N3O3/c1-9(18)15-6-5-10-8-16-13-4-3-11(7-12(10)13)17-14(19)20-2/h3-4,7-8,16H,5-6H2,1-2H3,(H,15,18)(H,17,19). InChi Key: MPZVHKLZCUEJFO-UHFFFAOYSA-N.