4-Aminobenzoic Acid hydrazide

4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO, IC50 = 0.3 µM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in isolated human neutrophils with IC50 values of 16 and 2.2 µM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.Formal Name: 4-amino-benzoic acid, hydrazide. CAS Number: 5351-17-7. Synonyms: 4-ABAH, Myeloperoxidase Inhibitor 1, NSC 640. Molecular Formula: C7H9N3O. Formula Weight: 151.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 14 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 282 nm. SMILES: NC1=CC=C(C(NN)=O)C=C1. InChi Code: InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11). InChi Key: WPBZMCGPFHZRHJ-UHFFFAOYSA-N.