12-Deoxywithastramonolide

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots. It has anti-inflammatory activity, reducing Tnf-alpha and increasing Il-10 production in mice following oral administration at doses ranging from 50-200 mg/kg. 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal cancer cells (IC50s = 47.1 and 29.8 µM, respectively).Formal Name: 6alpha,7alpha-epoxy-5alpha,22R,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid delta-lactone. CAS Number: 60124-17-6. Synonyms: Baimantuoluoside C aglycone, 27-Hydroxywithanolide B. Molecular Formula: C28H38O6. Formula Weight: 470.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 0.1 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 224 nm. SMILES: CC(C1)=C(CO)C(O[C@@]1([H])[C@@H](C)[C@@]2([H])CC[C@@]3([H])[C@]4([H])[C@H]5[C@H](O5)[C@@]([C@@]6(C)[C@@]4([H])CC[C@@]32C)(O)CC=CC6=O)=O. InChi Code: InChI=1S/C28H38O6/c1-14-12-20(33-25(31)16(14)13-29)15(2)17-7-8-18-22-19(9-11-26(17,18)3)27(4)21(30)6-5-10-28(27,32)24-23(22)34-24/h5-6,15,17-20,22-24,29,32H,7-13H2,1-4H3/t15-,17+,18-,19-,20+,22-,23-,24-,26+,27-,28-/m0/s1. InChi Key: AWVMHXZWAKRDGG-MEBIVHGNSA-N. Origin: Plant/Withania somnifera.