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(±)11(12)-EET
Artikelnummer: Cay50511-50
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET...
| Schlagworte: | (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 87173-81-7 |
| MW: | 320.5 D |
ab 61,00 €
Docosahexaenoic Acid
Artikelnummer: Cay90310-50
Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils. It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes. DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from...
| Schlagworte: | Cervonic Acid, DHA, 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid |
| Anwendung: | Bioactive lipid studies |
| CAS | 6217-54-5 |
| MW: | 328.5 D |
ab 60,00 €
Quest Fluo-8(TM), AM
Artikelnummer: ABD-21080
Developed to improve cell loading and calcium response while maintaining the convenient Fluo-3 and Fluo-4 spectral wavelength.Only requires RT and is 2 times brighter than Fluo-4 AM, and 4 times brighter than Fluo-3 AM.
| Anwendung: | Calcium indicator |
ab 139,00 €
Latrunculin A
Artikelnummer: Cay10010630-100
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
| Schlagworte: | NSC 613011,... |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421.6 D |
ab 66,00 €
Bafilomycin A1
Artikelnummer: Cay11038-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Schlagworte: | NSC 381866,... |
| Anwendung: | V-ATPase inhibitor |
| CAS | 88899-55-2 |
| MW: | 622.8 D |
ab 125,00 €
Ionomycin (calcium salt)
Artikelnummer: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Schlagworte: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
| Anwendung: | Calcium ionophore |
| CAS | 56092-82-1 |
| MW: | 747.1 D |
ab 44,00 €
Metformin (hydrochloride)
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Anwendung: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
ab 31,00 €
Hygromycin B (hydrate)
Artikelnummer: Cay14291-1
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...
| Schlagworte: | O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N3-methyl-D-strep... |
| Anwendung: | Antibiotic |
| MW: | 527.5 D |
ab 100,00 €
FCCP
Artikelnummer: Cay15218-10
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
| Schlagworte: | Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
| Anwendung: | Inhibits mitochondrial oxidative phosphorylation, uncoupling reagent |
| CAS | 370-86-5 |
| MW: | 254.2 D |
ab 88,00 €
Ganglioside GT1b (bovine) (sodium salt)
Artikelnummer: Cay15588-5
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 µM, respectively. Ganglioside GT1b-containing...
| Schlagworte: | Ganglioside G1 Mixture |
| Anwendung: | Trisialoganglioside |
| MW: | 2126.3 D |
ab 145,00 €
Leukotriene B4
Artikelnummer: Cay20110-25
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
| Schlagworte: | LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 71160-24-2 |
| MW: | 336.5 D |
ab 193,00 €
(±)5(6)-EET
Artikelnummer: Cay50211-50
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior...
| Schlagworte: | (±)5,6-EpETrE, (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 87173-80-6 |
| MW: | 320.5 D |
ab 61,00 €