Human TSPAN12 (Tetraspanin-12) ELISA Kit (HUFI05913)

Human TSPAN12 (Tetraspanin-12) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human TSPAN12 (Tetraspanin-12) in serum, plasma & cell culture supernatant samples. The Human TSPAN12 (Tetraspanin-12) ELISA Kit accurately measures natural Human TSPAN12 (Tetraspanin-12) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human TSPAN12 (Tetraspanin-12) peptide. Protein function: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP- dependent cleavage activity. [The UniProt Consortium]