Human RFC1 (Reduced Folate Carrier 1) ELISA Kit (HUFI04748)

Human RFC1 (Reduced Folate Carrier 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human RFC1 (Reduced Folate Carrier 1) in serum, plasma & cell culture supernatant samples. The Human RFC1 (Reduced Folate Carrier 1) ELISA Kit accurately measures natural Human RFC1 (Reduced Folate Carrier 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human RFC1 (Reduced Folate Carrier 1) peptide. Protein function: Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (PubMed:31126740, PubMed:31511694). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). [The UniProt Consortium]