CD178 (human) ELISA Set

Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition., Assay Range: 62.5-2000 pg/ml, Sensitivity: 12 pg/ml, Cross reaction: No cross reactivity with other human soluble molecules, Incubation time: From sample to end 3h45, Sample Types: Serum, Plasma, Cell culture supernatant, Sample Size: 100 µl Protein function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen- activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). [The UniProt Consortium]