Anti-WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3,

WHSC1L1 is a histone methyltransferase. This protein preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.