Anti-PTEN (IHC)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
IHC-00358-T 10 µl (5+ slides) -

3 - 9 Werktage*

131,00 €
IHC-00358 100 µl (50+ slides) -

3 - 9 Werktage*

493,00 €
 
Protein function: Tumor suppressor. Acts as a dual-specificity protein phosphatase,... mehr
Produktinformationen "Anti-PTEN (IHC)"
Protein function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. [The UniProt Consortium]
Schlagworte: Anti-PTEN, Anti-MMAC1, Anti-Phosphatase and tensin homolog, Anti-Mutated in multiple advanced cancers 1, Anti-Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Hersteller: Bethyl Laboratories
Hersteller-Nr: IHC-00358

Eigenschaften

Anwendung: IHC, IHC-IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Duckbill Platypus, Tasmanian Devil, White-tufted-ear Marmoset, Domestic Water Buffalo)
Immunogen: synthetic peptide. The epitope recognized by IHC-00358 maps to a region between residue 350 and the C-terminus (residue 403) of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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