Anti-NR1I3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-60529.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-60529.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-60529.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of... mehr
Produktinformationen "Anti-NR1I3"
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. [The UniProt Consortium]
Schlagworte: Anti-CAR, Anti-NR1I3, Anti-Constitutive active response, Anti-Orphan nuclear receptor MB67, Anti-Constitutive androstane receptor, Anti-Constitutive activator of retinoid response, Anti-Nuclear receptor subfamily 1 group I member 3, NR1I3 Polyclonal Antib
Hersteller: Elabscience
Hersteller-Nr: E-AB-60529

Eigenschaften

Anwendung: WB, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Recombinant protein of human NR1I3

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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