Anti-LSD1 (aa 450-500)

LSD1, the first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domaine. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.Synonyms: KDM1. Immunogen: synthetic peptide from human LSD1 amino acids 450-500. Formulation: (Request formulation change), 100 µg of protein A-purified IgG. Storage Buffer: 200 µl PBS with 0.05% BSA and 0.05% sodium azide. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.