Zu "K11450" wurden 99 Artikel gefunden!
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GSK690
Artikelnummer: Cay45336-10
GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). It potentiates reductions in viability of SJCRH30...
| Schlagworte: | 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-benzonitrile |
| Anwendung: | LSD1 inhibitor |
| CAS | 2101305-84-2 |
| MW: | 369.47 D |
ab 97,00 €
GSK690 (hydrochloride)
Artikelnummer: Cay45320-1
GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). GSK690 potentiates reductions in viability of SJCRH30...
| Schlagworte: | 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-benzonitrile, monohydrochloride |
| Anwendung: | Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibitor |
| CAS | 2436760-79-9 |
| MW: | 405.93 D |
ab 69,00 €
Anti-Recombinant KDM1A, clone 3P11
Artikelnummer: E-AN301024L.100
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
| Schlagworte: | Anti-KDM1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A, Anti-Flavin-containing... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
SP-2509
Artikelnummer: Cay15487-5
Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP-2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP-2509 attenuates the binding of LSD1 to...
| Schlagworte: | HCI-2509, LSD1 Inhibitor VII, 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Anwendung: | LSD1 inhibitor |
| CAS | 1423715-09-6 |
| MW: | 437.9 D |
ab 51,00 €
Anti-BHC110/LSD1
Artikelnummer: A300-215A
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a...
| Schlagworte: | Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A,... |
| Anwendung: | WB, IP, IHC, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
ORY-1001
Artikelnummer: Cay19136-1
ORY-1001 is an inhibitor of lysine-specific demethylase 1 (LSD1), an oxidase that demethylates histone 3 at lysine 4 (H3K4) and H3K9 (IC50 = 0.018 µM). It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM). ORY-1001 also...
| Schlagworte: | RG-6016, rel-N1-[(1R,2S)-2-phenylcyclopropyl]-1,4-cyclohexanediamine, dihydrochloride |
| Anwendung: | LSD1 inhibitor |
| CAS | 1431326-61-2 |
| MW: | 303.3 D |
ab 51,00 €
LSD1 Inhibitor Screening Assay Kit
Artikelnummer: Cay700120-96
Lysine-specific demethylase 1 (LSD1) is a histone demethylase whose actions on specific lysine residues repress transcription of chromosomal DNA. LSD1 also inhibits the tumor suppressor activity of p53 by demethylating a specific lysine residue. Inhibitors of LSD1 are important tools used to elucidate mechanisms of...
| Schlagworte: | Lysine-Specific Demethylase 1 |
| Anwendung: | LSD1 inhibitor screening |
| Spezies-Reaktivität: | human |
499,00 €
GSK-LSD1 (hydrochloride)
Artikelnummer: Cay16439-5
Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO). LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression. It also...
| Schlagworte: | rel-N-[(1R,2S)-2-phenylcyclopropyl]-4-piperidinamine, dihydrochloride |
| Anwendung: | Irreversible LSD1 inhibitor |
| CAS | 2102933-95-7 |
| MW: | 289.2 D |
ab 51,00 €
GSK2879552
Artikelnummer: Cay19403-5
GSK2879552 is a selective, orally bioavailable, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor for element-1-silencing transcription factor (CoREST) activity. Inhibition of LSD1 via GSK2879552 has been shown to enhance H3K4 methylation and to increase the expression of...
| Schlagworte: | 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-benzoic acid |
| Anwendung: | LSD1 inhibitor |
| CAS | 1401966-69-5 |
| MW: | 364.5 D |
ab 51,00 €
Tranylcypromine (2-PCPA), LSD1 inhibitor
Artikelnummer: BPS-27305
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| Anwendung: | LSD1 inhibitor |
| CAS | 13492-01-8 |
| MW: | 364.5 D |
464,00 €
SP2509
Artikelnummer: SYN-1212-M001
Soluble in DMSO. LSD1 is a promising target for cancer therapy. Epigenetic control of histone methylation is frequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer. siRNA knockdown of LSD1 has been shown to suppress growth of cancer cells. SP-2528 is a selective and reversible LSD1...
| Schlagworte: | SP-2509 |
| Anwendung: | LSD1 inhibitor |
| CAS | 1423715-09-6 |
| MW: | 437,9 D |
ab 185,00 €
Tranylcypromine (hydrochloride)
Artikelnummer: Cay10010494-250
Tranylcypromine is an irreversible, mechanism-based inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 20.7 µM in a cell-free assay). It also irreversibly inhibits monoamine oxidase A (MAO-A) and MAO-B with IC50 values of 2.3 and 0.95 µM, respectively. Tranylcypromine inhibits nucleosomal demethylation of...
| Schlagworte: | trans-2-Phenylcyclopropylamine, 2-PCPA, (1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride |
| Anwendung: | LSD1 inhibitor |
| CAS | 1986-47-6 |
| MW: | 169.7 D |
ab 40,00 €