Zu "K11450" wurden 94 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant KDM1A, clone 3P11
Artikelnummer: E-AN301024L.100
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
| Schlagworte: | Anti-KDM1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A, Anti-Flavin-containing... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
IMG-7289 (tosylate)
Artikelnummer: Cay43733-1
IMG-7289 is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1). It induces cell cycle arrest at the S phase in SET-2 acute megakaryoblastic leukemia cells and apoptosis in Ba/F3 murine hematopoietic cells expressing Jak2 containing a valine-to-phenylalanine substitution at position 617 (Jak2V617F)...
| Schlagworte: | Bomedemstat ditosylate, N-[(1S)-4-[[(1R... |
| Anwendung: | Irreversible LSD1 inhibitor |
| CAS | 1990504-72-7 |
| MW: | 864 D |
ab 102,00 €
CC-90011
Artikelnummer: Cay32727-10
CC-90011 is an inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 0. nM). It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B at 10 µM. CC-90011 induces differentiation in THP-1 cells (EC50 = 7 nM) and inhibits the proliferation of NCI H1417 small cell lung cancer (SCLC) cells (EC50 = 6...
| Schlagworte: | LSD1 Inhibitor 7, LSD1-IN-7, Lysine-specific Demethylase 1 Inhibitor 7, Lysine-specific Demethylase 1-IN-7,... |
| Anwendung: | LSD1 inhibitor |
| CAS | 2097523-60-7 |
| MW: | 609.64 D |
ab 146,00 €
SP-2577
Artikelnummer: Cay43468-10
An LSD1 inhibitor (IC50 = 13 nM), induces cell death in a panel of 12 ovarian cancer cell lines expressing mutant SWI/SNF (IC50s = 0.013-2.819 µM), increases secretion of IFN-gamma, IFN-beta, IL-1beta, IL-2, and IL-6 in COV434 cells, decreases the viability of primary NKT cells and T cells and reduces the...
| Schlagworte: | Seclidemstat, 3-[(4-methyl-1-piperazinyl)sulfonyl]-benzoic acid, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Anwendung: | LSD1 inhibitor |
| CAS | 1423715-37-0 |
| MW: | 450.94 D |
ab 72,00 €
INCB 059872 (hydrochloride)
Artikelnummer: Cay43470-1
An LSD1 inhibitor (IC50 = 18 nM), decreases proliferation in THP-1 and MV4-11 cells and increases the levels of CD11b in THP-1 cells when used at a concentration of 100 nM
| Schlagworte: | 1-[[4-(methoxymethyl)-4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-cyclobutanecarboxylic acid,... |
| Anwendung: | LSD1 inhibitor |
| CAS | 3062683-32-0 |
| MW: | 459.5 D |
ab 92,00 €
SP-2509
Artikelnummer: Cay15487-5
Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP-2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP-2509 attenuates the binding of LSD1 to...
| Schlagworte: | HCI-2509, LSD1 Inhibitor VII, 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Anwendung: | LSD1 inhibitor |
| CAS | 1423715-09-6 |
| MW: | 437.9 D |
ab 49,00 €
Anti-BHC110/LSD1
Artikelnummer: A300-215A
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a...
| Schlagworte: | Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A,... |
| Anwendung: | WB, IP, IHC, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
ORY-1001
Artikelnummer: Cay19136-1
ORY-1001 is an inhibitor of lysine-specific demethylase 1 (LSD1), an oxidase that demethylates histone 3 at lysine 4 (H3K4) and H3K9 (IC50 = 0.018 µM). It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM). ORY-1001 also...
| Schlagworte: | RG-6016, rel-N1-[(1R,2S)-2-phenylcyclopropyl]-1,4-cyclohexanediamine, dihydrochloride |
| Anwendung: | LSD1 inhibitor |
| CAS | 1431326-61-2 |
| MW: | 303.3 D |
ab 49,00 €
GSK-LSD1 (hydrochloride)
Artikelnummer: Cay16439-5
Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO). LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression. It also...
| Schlagworte: | rel-N-[(1R,2S)-2-phenylcyclopropyl]-4-piperidinamine, dihydrochloride |
| Anwendung: | Irreversible LSD1 inhibitor |
| CAS | 2102933-95-7 |
| MW: | 289.2 D |
ab 49,00 €
LSD1 Inhibitor Screening Assay Kit
Artikelnummer: Cay700120-96
Lysine-specific demethylase 1 (LSD1) is a histone demethylase whose actions on specific lysine residues repress transcription of chromosomal DNA. LSD1 also inhibits the tumor suppressor activity of p53 by demethylating a specific lysine residue. Inhibitors of LSD1 are important tools used to elucidate mechanisms of...
| Schlagworte: | Lysine-Specific Demethylase 1 |
| Anwendung: | LSD1 inhibitor screening |
| Spezies-Reaktivität: | human |
484,00 €
GSK2879552
Artikelnummer: Cay19403-5
GSK2879552 is a selective, orally bioavailable, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor for element-1-silencing transcription factor (CoREST) activity. Inhibition of LSD1 via GSK2879552 has been shown to enhance H3K4 methylation and to increase the expression of...
| Schlagworte: | 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-benzoic acid |
| Anwendung: | LSD1 inhibitor |
| CAS | 1401966-69-5 |
| MW: | 364.5 D |
ab 49,00 €
Tranylcypromine (2-PCPA), LSD1 inhibitor
Artikelnummer: BPS-27305
.
| Anwendung: | LSD1 inhibitor |
| CAS | 13492-01-8 |
| MW: | 364.5 D |
464,00 €