Anti-Hif-1alpha hydroxy-Pro564

Anti-Hif-1alpha hydroxy-Pro564
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
100-401-A25 100 µl - -

1 - 9 Werktage

471,00 €
 
Protein function: Functions as a master transcriptional regulator of the adaptive response to... mehr
Produktinformationen "Anti-Hif-1alpha hydroxy-Pro564"
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. [The UniProt Consortium]
Schlagworte: Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8, Anti-Hypoxia-inducible factor 1-alpha
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 100-401-A25

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Monkey, Mouse, Rat, Dog, Bovine, Xenopus)
Immunogen: synthetic peptide corresponding to a region surrounding the P564 of human HIF-1a

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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