Anti-HIF1-alpha

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-286A-T 10 µl (2 µg) -

2 - 8 Werktage*

164,00 €
A300-286A 100 µl -

2 - 8 Werktage*

588,00 €
 
Protein function: Functions as a master transcriptional regulator of the adaptive response to... mehr
Produktinformationen "Anti-HIF1-alpha"
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. [The UniProt Consortium]
Schlagworte: Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8, Anti-Hypoxia-inducible factor 1-alpha
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-286A

Eigenschaften

Anwendung: WB, IP, IHC, ICC-IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse (Erwartet: rat, chicken, bovine)
Immunogen: synthetic peptide. The epitope recognized by A300-286A-T maps to a region between residues 775 and the C-terminus (residue 826) of human hypoxia-inducible factor 1, alpha subunit using the numbering given in Swiss-Prot entry Q16665 (GeneID 3091).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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