Zu "K08268" wurden 149 Artikel gefunden!
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Anti-HIF-1alpha (C-Term)
Artikelnummer: Cay10006421-1
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response...
| Schlagworte: | Anti-BHLHE78, Anti-bHLHe78, Anti-bHLHe78, Anti-ARNT-interacting protein, Anti-ARNT-interacting protein, Anti-PAS... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
431,00 €
HRE Luciferase Reporter ME-180 Cell Line
Artikelnummer: BPS-82436
HRE Luciferase Reporter ME-180 Cell Line is designed to monitor the activity of hypoxia-inducible factors (HIFs). It contains a firefly luciferase reporter driven by multiple copies of hypoxia response element (HRE) located upstream of the minimal TATA promoter. As oxygen becomes rate limiting, HIFs form...
| Schlagworte: | bHLHe78, BHLHE78, HIF1-alpha, HIF-1-alpha, Member of PAS protein 1, ARNT-interacting protein, PAS domain-containing... |
| Anwendung: | Hypoxia-related signaling pathway studies |
| Spezies-Reaktivität: | human |
6.269,00 €
Hypoxia-inducible factor 1-alpha (HIF1A), partial,...
Artikelnummer: CSB-EP624113HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 579-826aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR...
| Schlagworte: | BHLHE78, bHLHe78, HIF1-alpha, HIF-1-alpha, Member of PAS protein 1, ARNT-interacting protein, PAS domain-containing... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 31 kD |
ab 219,00 €
HIF-1 alpha Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01709-100ug
Description: HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under...
| Schlagworte: | HIF1-ALPHA, HIF1-alpha, HIF1, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),... |
| MW: | 28.4 kD |
699,00 €
HIF-1 inhibitor-4
Artikelnummer: TGM-T67767-100mg
Description: HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1alpha protein level without affecting its mRNA level. Target: HIF. Smiles: IC1=CC=C(NC(=O)C2=CC=C(CN3CCOCC3)C=C2)C=C1. References: Nagao S, et al. Synthesis and structure-activity...
| Schlagworte: | HIF-1 inhibitor-4 |
| Anwendung: | HIF-1 inhibitor |
| CAS | 333357-56-5 |
| MW: | 422.26 D |
ab 42,00 €
Anti-HIF1-alpha
Artikelnummer: A300-286A
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein...
| Schlagworte: | Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1,... |
| Anwendung: | WB, IP, IHC, ICC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 178,00 €
Echinomycin
Artikelnummer: TGM-T15197-1mg
Description: Echinomycin is a cell-permeable hypoxia-inducible factor-1 (HIF-1) DNA-binding activity inhibitor. Echinomycin selectively inhibits the cancer stem cells (CSCs, IC50: 29.4 pM). Target: Others. Smiles:...
| Schlagworte: | Quinomycin A, NSC-13502 |
| Anwendung: | Apoptosis inducer |
| CAS | 512-64-1 |
| MW: | 1101.26 D |
294,00 €
GN44028
Artikelnummer: TGM-T15396-100mg
Description: GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1alpha transcriptional activity. However, It can not be suppressing HIF-1alpha mRNA expression, HIF-1alpha protein...
| Schlagworte: | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
| Anwendung: | HIF-1alpha transcriptional activity inhibitor |
| CAS | 1421448-26-1 |
| MW: | 305.33 D |
ab 63,00 €
LW6
Artikelnummer: TGM-T3494-100mg
Description: LW6 (HIF-1alpha inhibitor) is a novel HIF-1 inhibitor. Target: HIF/HIF Prolyl-Hydroxylase, HIF, Apoptosis, Dehydrogenase. Smiles: COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C2C3CC4CC(C3)CC2C4)c1. References: Naik R , Won M , Ban H S , et al. Synthesis and Structure-Activity Relationship Study of Chemical...
| Schlagworte: | LW8, CAY10585, HIF-1alpha inhibitor |
| Anwendung: | HIF-1alpha accumulation inhibition |
| CAS | 934593-90-5 |
| MW: | 435.51 D |
ab 40,00 €
Amifostine
Artikelnummer: TGM-T3289-100mg
Description: Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity. Target: HIF/HIF Prolyl-Hydroxylase, Others. Smiles: NCCCNCCSP(O)(O)=O. References: Kouvaris JR. Oncologist. 12 (6): 738-47
| Schlagworte: | Gammaphos, WR2721, Ethyol |
| Anwendung: | Chemopreventive agent |
| CAS | 20537-88-6 |
| MW: | 214.22 D |
ab 31,00 €
HIF-1alpha inhibitor-1
Artikelnummer: TGM-T71661-100mg
Description: HIF-1alpha inhibitor-1 is a HIF-1 alpha inhibitor. Target: Others. Smiles: OC1=CC(=CN=C1C(NCC(O)=O)=O)C2=CC=C(C#N)C=C2
| Anwendung: | HIF-1alpha inhibitor |
| CAS | 1000025-14-8 |
| MW: | 297.27 D |
ab 1.520,00 €
Vitexin
Artikelnummer: TGM-T6S1369-100mg
Description: 1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and alpha-glucosidase inhibitory activities. 4. Vitexin can either inhibit or induce activities of CYP2C11 and CYP3A1. 5. Vitexin induces the...
| Schlagworte: | Apigenin-8-C-glucoside |
| Anwendung: | alpha-Glucosidase inhibitor, Antioxidant, HIF-1 alpha inhibitor |
| CAS | 3681-93-4 |
| MW: | 432.38 D |
ab 31,00 €