Zu "K08268" wurden 164 Artikel gefunden!
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Anti-HIF-1alpha (C-Term)
Artikelnummer: Cay10006421-1
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response...
| Schlagworte: | Anti-BHLHE78, Anti-bHLHe78, Anti-bHLHe78, Anti-ARNT-interacting protein, Anti-ARNT-interacting protein, Anti-PAS... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
468,00 €
Anti-HIF1A / HIF-1 alpha, clone 31H88
Artikelnummer: NSJ-FY12702
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. HIF1A antibody detects hypoxia inducible factor 1 alpha, encoded by the HIF1A gene. HIF-1 alpha is a transcription factor that regulates cellular responses to low oxygen. Under normoxia, HIF-1 alpha is...
| Schlagworte: | Anti-HIF1A, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8,... |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-HIF1-alpha
Artikelnummer: A300-286A
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein...
| Schlagworte: | Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1,... |
| Anwendung: | WB, IP, IHC, ICC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
HIF-1alpha Protein (Sumo Tag) (human), recombinant
Artikelnummer: E-PDEH101145.1
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen...
| Schlagworte: | BHLHE78, bHLHe78, HIF1-alpha, HIF-1-alpha, Member of PAS protein 1, ARNT-interacting protein, PAS domain-containing... |
| Ursprungsart: | human |
ab 192,00 €
HIF-1alpha Protein (His Tag) (human), recombinant
Artikelnummer: E-PDEH101146.1
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen...
| Schlagworte: | BHLHE78, bHLHe78, HIF1-alpha, HIF-1-alpha, Member of PAS protein 1, ARNT-interacting protein, PAS domain-containing... |
| Ursprungsart: | human |
ab 192,00 €
PX-478
Artikelnummer: Cay10005189-5
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1alpha in cancer cells, resulting in reduced expression of HIF-1alpha target genes. It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1alpha level. PX-478 can also increase chemo- or...
| Schlagworte: | 4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride |
| Anwendung: | HIF-1 alpha inhibitor |
| CAS | 685898-44-6 |
| MW: | 394.1 D |
ab 87,00 €
CAY10585
Artikelnummer: Cay10012682-5
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1alpha subunit and HIF-1beta subunit. Whereas the HIF-1beta subunit is constitutively expressed, the HIF-1alpha subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular...
| Schlagworte: | Hypoxia-Inducible Factor-1alpha Inhibitor, 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-benzoic... |
| Anwendung: | HIF-1alpha accumulation inhibition |
| CAS | 934593-90-5 |
| MW: | 435.5 D |
ab 25,00 €
Echinomycin
Artikelnummer: Cay11049-1
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of...
| Schlagworte: | Antibiotic A 654I, NSC 13502, NSC 526417, Quinomycin A, SK 302B,... |
| Anwendung: | Apoptosis inducer |
| CAS | 512-64-1 |
| MW: | 1101.3 D |
ab 145,00 €
Anti-HIF1-alpha (IHC)
Artikelnummer: IHC-00460
Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein...
| Schlagworte: | Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1,... |
| Anwendung: | IHC, ICC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Echinomycin
Artikelnummer: BVT-0267-M001
Antibiotic, Antitumor compound, Powerful, selective inhibitor of nucleic acid synthesis in vitro, Potent hypoxia-inducible factor 1 (HIF-1) DNA binding activity inhibitor, Apoptosis inducer, Antibacterial, antifungal and antiviral. Isolated from Streptomyces echinatus (DSM 40013).
| Schlagworte: | Quinomycin A |
| Anwendung: | Apoptosis inducer |
| CAS | 512-64-1 |
| MW: | 1101,3 D |
ab 90,00 €
Amifostine
Artikelnummer: LKT-A4933.100
White or almost white crystalline powder. Amifostine is a chemopreventive drug used to selectively protect normal tissues from the side effects of chemotherapy drugs such as cyclophosphmide, mitomucin-C and cisplatin, and ionising radiation therapy.
| Schlagworte: | Ethiofos, Gammaphos, SAPEP, Ethyol |
| Anwendung: | Chemopreventive agent |
| CAS | 20537-88-6 |
| MW: | 214,22 D |
ab 118,00 €
Chetomin
Artikelnummer: Cay14437-1
Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1alpha and HIF-2alpha to p300 at low nanomolar concentrations. Chetomin effectively attenuates...
| Schlagworte: | NSC 289491,... |
| Anwendung: | Potent immunosuppressor |
| CAS | 1403-36-7 |
| MW: | 710.9 D |
ab 274,00 €