Anti-HIF-1 alpha

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F50744-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F50744-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Hypoxia-inducible factor-1 (HIF1) is a transcription... mehr
Produktinformationen "Anti-HIF-1 alpha"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. [The UniProt Consortium]
Schlagworte: Anti-HIF1A, Anti-BHLHE78, Anti-bHLHe78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8, Anti-Hypoxia-inducible factor 1-alpha, HIF-1 alpha Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F50744

Eigenschaften

Anwendung: IHC, WB, IF, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: A portion of amino acids 728-757 from the human protein was used as the immunogen for this HIF-1 alpha antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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