Anti-GRK2

Polyclonal Antibody against Human GRK2, Gene description: G protein-coupled receptor kinase 2, Alternative Gene Names: ADRBK1, BARK1, Validated applications: ICC, WB, Uniprot ID: P25098, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). [The UniProt Consortium] Mouse gene identity: 98% Rat gene identity: 98%