Anti-Beta-catenin

Anti-Beta-catenin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-011A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-011A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A302-011A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence... mehr
Produktinformationen "Anti-Beta-catenin"
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. [The UniProt Consortium]
Schlagworte: Anti-CTNNB, Anti-CTNNB1, Anti-Beta-catenin, Anti-Catenin beta-1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-011A-T

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat, X. Laevis, Bovine, Dog)
Immunogen: synthetic peptide. The epitope recognized by A302-011A-T maps to a region between residue 710 and 760 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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