Anti-Bcl-xL

Anti-Bcl-xL Antibody is supplied as ion exchange chromatography purified IgG. Cross reactivity with Bcl-xL from other sources has not been determined. Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. [The UniProt Consortium]