Zu "K04570" wurden 117 Artikel gefunden!

1 von 10 Seiten
Für die Filterung wurden keine Ergebnisse gefunden!
-10 %
Rabattaktion
Mouse Bcl2L (B-Cell CLL/Lymphoma 2 Like Protein) ELISA Kit
Mouse Bcl2L (B-Cell CLL/Lymphoma 2 Like Protein) ELISA Kit

Artikelnummer: ELK-ELK7209.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Bcl2L. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Bcl2L. Next,...
Schlagworte: Bcl2l, Bcl2l1, Bcl2-L-1, Bcl-2-like protein 1, Apoptosis regulator Bcl-X
Anwendung: ELISA
Spezies-Reaktivität: mouse
365,00 € ab 328,50 €
Bewerten
-10 %
Rabattaktion
Anti-Bcl-Xl
Anti-Bcl-Xl

Artikelnummer: ELK-EA258.100

Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions. Protein function: Potent inhibitor of cell death. Inhibits...
Schlagworte: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, Bcl-Xl Rabbit pAb
Anwendung: IHC
Wirt: Rabbit
Spezies-Reaktivität: human
283,00 € 254,70 €
Bewerten
A-1155463
A-1155463

Artikelnummer: Cay27369-1

A-1155463 is an inhibitor of Bcl-xL (Ki = is = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected...
Schlagworte: 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluoro...
Anwendung: Bcl-xL inhibitor
CAS 1235034-55-5
MW: 669.8 D
ab 45,00 €
Bewerten
DT2216
DT2216

Artikelnummer: Cay37311-1

DT2216 is a proteolysis-targeting chimera (PROTAC) composed of the Bcl-2 family inhibitor ABT-263 (Cay-11500) conjugated to a von Hippel-Lindau (VHL) E3 ligase ligand. It selectively induces degradation of Bcl-xL in MOLT-4 T cell acute lymphoblastic leukemia (T-ALL) cells with a 50% degradation concentration (DC50)...
Schlagworte: (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperaz...
Anwendung: Bcl-xL degradation driving PROTAC
CAS 2365172-42-3
MW: 1542.4 D
ab 35,00 €
Bewerten
Gossypol
Gossypol

Artikelnummer: Cay14482-100

Gossypol is a racemic mixture of natural polyphenols isolated from parts of the cotton plant (genus Gossypium). It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations....
Schlagworte: BL 193, NSC 56817, NSC 624336, Pogosin,...
Anwendung: Bcl2 / Bcl-xL inhibitor
CAS 303-45-7
MW: 518.6 D
ab 100,00 €
Bewerten
WEHI-539
WEHI-539

Artikelnummer: Cay21478-1

WEHI-539 is an inhibitor of Bcl-xL (IC50 = 1.1 nM) that demonstrates more than 400-fold selectivity for Bcl-xL over Bcl-2, Mcl-1, Bcl-W, or A1. It has been shown to induce apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells. WEHI-539 can be used as a tool for distinguishing...
Schlagworte: 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiaz...
Anwendung: Bcl-xL inhibitor
CAS 1431866-33-9
MW: 583.7 D
ab 77,00 €
Bewerten
Obatoclax (mesylate)
Obatoclax (mesylate)

Artikelnummer: Cay11499-5

Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...
Schlagworte: GX15-070, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate
Anwendung: Antagonist of Bcl-2 family members containing four Bcl-2 homology domains
CAS 803712-79-0
MW: 413.5 D
ab 84,00 €
Bewerten
Anti-Bcl-xL
Anti-Bcl-xL

Artikelnummer: A300-284A

Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Schlagworte: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human
ab 164,00 €
Bewerten
A-1331852
A-1331852

Artikelnummer: Cay22963-1

A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the...
Schlagworte: 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)...
Anwendung: BCL-XL inhibitor
CAS 1430844-80-6
MW: 658.8 D
ab 130,00 €
Bewerten
Anti-BCL-XL (FITC), clone 7B2.5
Anti-BCL-XL (FITC), clone 7B2.5

Artikelnummer: ARG21415.50

Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Schlagworte: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X
Anwendung: FC, IHC (paraffin), ICC, IF, WB, ELISA
Wirt: Mouse
Spezies-Reaktivität: human, mouse, rat, rhesus monkey
544,00 €
Bewerten
Anti-BCL-XL (PE), clone 7B2.5
Anti-BCL-XL (PE), clone 7B2.5

Artikelnummer: ARG21417.50

Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Schlagworte: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X
Anwendung: FC, IHC (paraffin), ICC, IF, WB, ELISA
Wirt: Mouse
Spezies-Reaktivität: human, mouse, rat, rhesus monkey
592,00 €
Bewerten
Anti-BCL-XL, clone 2H12
Anti-BCL-XL, clone 2H12

Artikelnummer: ARG22305.50

Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2...
Schlagworte: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X
Anwendung: WB, IP, FC, IHC (paraffin), ELISA
Wirt: Mouse
Spezies-Reaktivität: mouse, rat, human
480,00 €
Bewerten
1 von 10 Seiten