Zu "K04570" wurden 132 Artikel gefunden!
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DT-2216
Artikelnummer: LKT-D760022.1
DT-2216 is a proteolysis targeting chimera degrader which specifically targets Bcl-xL. SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCC(=O)N4CCN(CC4)CCC(CSC5=CC=CC=C5)NC6=C(C=C(C=C6)S(=O)(=O)NC(=O)C7=CC=C(C=C7)N8CCN(CC8)CC9=C(CCC(C9)(C)C)C1=CC=C(C=C1)Cl)S(=O)(=O)C(F)(F)F)O
| Schlagworte: | DT2216,... |
| Anwendung: | BCL-XL specific degrader |
| CAS | 2365172-42-3 |
| MW: | 1542.36 D |
ab 275,00 €
BCL-XL Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-02431-100ug
Description: BCL-XL Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.2 kDa and the accession number is A0A0S2Z3C5.
| Schlagworte: | BCL2L, BCLXS, BCL2-like 1, bcl-xL, BCL-XL/S, bcl-xS, PPP1R52, BCLX, Bcl-X, BCLXL |
| MW: | 25.2 kD |
ab 385,00 €
BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)
Artikelnummer: TGM-TMPY-02564-100ug
Description: BCL-XL Protein, Mouse, Recombinant (aa 1-212, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.2 kDa and the accession number is Q64373-1.
| Schlagworte: | BclX, Bcl2l, bcl-x, Bcl-XL, Bcl(X)L, BCL2-like 1, bcl2-L-1 |
| MW: | 25.2 kD |
699,00 €
A-1155463
Artikelnummer: TGM-T6748-10mg
Description: A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). Target: BCL. Smiles:...
| Schlagworte: | A1155463, A 1155463 |
| Anwendung: | Bcl-xL inhibitor |
| CAS | 1235034-55-5 |
| MW: | 669.79 D |
ab 40,00 €
A-1331852
Artikelnummer: TGM-T6749-100mg
Description: A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases. Target: BCL. Smiles: Cc1c(cnn1CC12CC3CC(CC(C3)C1)C2)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1. References: Leverson JD, et al. Sci Transl Med. 2015, 7(279):279ra40.
| Anwendung: | BCL-XL inhibitor |
| CAS | 1430844-80-6 |
| MW: | 658.81 D |
ab 46,00 €
Gossypol
Artikelnummer: TGM-T6518-100mg
Description: Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. Target: Dehydrogenase, BCL. Smiles: CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O. References: Ciereszko A, et al. Aquat Toxicol,...
| Schlagworte: | Pogosin, BL 193, NSC 56817 |
| Anwendung: | Bcl2 / Bcl-xL inhibitor |
| CAS | 303-45-7 |
| MW: | 518.55 D |
ab 37,00 €
WEHI-539
Artikelnummer: TGM-T13337L-1mg
Description: WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM). Target: BCL. Smiles: NCc1ccc(OCCCc2sc(nc2C(O)=O)-c2ccc3CCC\C(=N/Nc4nc5ccccc5s4)c3c2)cc1. References: Lessene G, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol. 2013 , 9(6):390-397.
| Anwendung: | Bcl-xL inhibitor |
| CAS | 1431866-33-9 |
| MW: | 583.72 D |
142,00 €
BH3I-1
Artikelnummer: TGM-T1493-100mg
Description: BH3I-1 (BHI1) is a Bcl-2 antagonist. Target: E1/E2/E3 Enzyme, BCL. Smiles: CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O. References: Degterev A, et al. Nat Cell Biol. 2001, 3(2):173-82.
| Schlagworte: | BHI1 |
| Anwendung: | Cell permeable apoptosis inducer, Bcl-xL BH3 peptide binding inhibitor |
| CAS | 300817-68-9 |
| MW: | 400.31 D |
ab 31,00 €
Human BCL2L1 Protein, hFc Tag
Artikelnummer: DIM-PME100567.10
Recombinant human BCL2L1 protein with C-terminal human Fc tag. BCL2L1(Met1-Arg212) hFc(Glu99-Ala330), Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release...
| Schlagworte: | Bcl-X, BCL-XL/S, BCL2L, BCLX, PPP1R52 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 49.9 kD |
ab 103,00 €
Anti-BCL2L1 Monoclonal, clone 3D1C1
Artikelnummer: CSB-MA0026131A0m.100
Host Species: Mouse. Isotype: IgG1. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%,Protein G purified. Target Name: BCL2L1. Antigen Species: Human
| Schlagworte: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, Bcl2-L-1,Apoptosis... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-BCL2L1
Artikelnummer: CSB-PA000986.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, Apoptosis regulator Bcl... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-BCL2L1
Artikelnummer: CSB-PA000987.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, Apoptosis regulator Bcl... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €