Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
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Prostaglandin E1
Artikelnummer: Cay13010-1
Prostaglandin E1 (PGE1) is a vasoactive prostaglandin and an active metabolite of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2 (Cay-14010) receptor subtypes EP1, EP2, EP3, and EP4, and the IP receptor (Kis = 36, 10, 1.1, 2.1, and 33 nM,...
| Schlagworte: | Alprostadil, PGE1, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 745-65-3 |
| MW: | 354.5 D |
ab 30,00 €
Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 77,00 €
15-keto Prostaglandin E1
Artikelnummer: Cay13680-1
15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.Formal Name: (11alpha,13E)-11-hydroxy-9,15-dioxo-prost-13-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5....
| Schlagworte: | 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 22973-19-9 |
| MW: | 352.5 D |
ab 88,00 €
Prostaglandin I2 (sodium salt)
Artikelnummer: Cay18220-1
Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...
| Schlagworte: | Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt |
| Anwendung: | Bioactive lipid assays |
| CAS | 61849-14-7 |
| MW: | 374.5 D |
ab 98,00 €
(±)11(12)-EET
Artikelnummer: Cay50511-50
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET...
| Schlagworte: | (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 87173-81-7 |
| MW: | 320.5 D |
ab 61,00 €
Docosahexaenoic Acid
Artikelnummer: Cay90310-50
Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils. It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes. DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from...
| Schlagworte: | Cervonic Acid, DHA, 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid |
| Anwendung: | Bioactive lipid studies |
| CAS | 6217-54-5 |
| MW: | 328.5 D |
ab 60,00 €
Latrunculin A
Artikelnummer: Cay10010630-100
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
| Schlagworte: | NSC 613011,... |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421.6 D |
ab 66,00 €
Bafilomycin A1
Artikelnummer: Cay11038-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Schlagworte: | NSC 381866,... |
| Anwendung: | V-ATPase inhibitor |
| CAS | 88899-55-2 |
| MW: | 622.8 D |
ab 125,00 €
Ionomycin (calcium salt)
Artikelnummer: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Schlagworte: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
| Anwendung: | Calcium ionophore |
| CAS | 56092-82-1 |
| MW: | 747.1 D |
ab 44,00 €
Metformin (hydrochloride)
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Anwendung: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
ab 31,00 €
Hygromycin B (hydrate)
Artikelnummer: Cay14291-1
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...
| Schlagworte: | O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N3-methyl-D-strep... |
| Anwendung: | Antibiotic |
| MW: | 527.5 D |
ab 100,00 €
FCCP
Artikelnummer: Cay15218-10
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
| Schlagworte: | Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
| Anwendung: | Inhibits mitochondrial oxidative phosphorylation, uncoupling reagent |
| CAS | 370-86-5 |
| MW: | 254.2 D |
ab 88,00 €